Neonatal Care Academy

Abnormal Interhemispheric Synchrony in Neonatal Hypoxic-Ischemic Encephalopathy

A Retrospective Pilot Study

Background: Abnormal interhemispheric synchrony has been described in many clinical compromises in brain function, but its prognostic value in neonatal hypoxic-ischemic encephalopathy (HIE) is unknown.

Objectives: The study aimed at describing the frequency of abnormal interhemispheric synchrony in infants with HIE and to explore its prognostic value. The main outcome was survival without major disabilities.

Methods: We performed a single-center retrospective cohort study and enrolled 40 neonates with HIE who underwent hypothermia.

Results: Abnormal interhemispheric synchrony was observed in 23% of the patients with HIE. Sensitivity and specificity values for predicting survival without major disabilities were 90 and 67% for seizures, 50 and 97% for status epilepticus, 60 and 97% for highly abnormal EEG in the first 48 h, and 80 and 97% for EEG asynchrony, respectively. The prognostic value of asynchrony improved to 100% sensitivity, whereas specificity remained unchanged, when associated with highly abnormal EEG within the first 48 h of life.

Conclusions: Abnormal interhemispheric synchrony was observed in a quarter of the patients with HIE. This pilot study suggests that the prognostic value of asynchrony is excellent, especially when combined with EEG background analysis.

August 22, 2017

0 responses on "Abnormal Interhemispheric Synchrony in Neonatal Hypoxic-Ischemic Encephalopathy"

Leave a Message

© 2022 Natus Medical Incorporated | legal notice | Privacy Policy
Thank you
Please validate your E-Mail in your inbox
We never share Your data with 3rd parties. We are safe.
with the Neonatal Care Academy Newsletter!
We inform you on new eSeminars, education courses, news and events.
Sign up TODAY and start benefiting.