aEEG is widely used in infants with hypoxic-ischemic encephalopathy and other scenarios for monitoring seizures and predicting brain injury and neurological outcome in preterm infants. However, knowledge of aEEG in relation to icteric infants remains limited and mostly concentrated on one single parameter of the aEEG. This study incorporates three individual component variables of aEEG, including amplitude, SWC, and electrographic seizures, and has shown the predictive and prognostic value of abnormal aEEG for neonatal hyperbilirubinemia.